Knowledge management system on flow and water quality modeling

Author name used in this publication: K. W. Chau2001-2002 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Probing gamma-ray emissions of Fermi-LAT pulsars with a non-stationary outer gap model

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An intelligent knowledge processing system on hydrodynamics and water quality modeling

Series: Lecture notes in computer scienceAuthor name used in this publication: K. W. ChauAuthor name used in this publication: O. WaiAuthor name used in this publication: Y. S. Li2001-2002 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

DIFFERENCES BETWEEN RADIO-LOUD AND RADIO-QUIET γ-RAY PULSARS AS REVEALED BY <i>FERMI</i>

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Inhibition of prostate cancer cell growth by human secreted PDZ domain-containing protein 2, a potential autocrine prostate tumor suppressor

A possible role of the PDZ domain-containing protein 2 (PDZD2) in prostate tumorigenesis has been suggested. Besides, PDZD2 is posttranslationally cleaved by a caspase-dependent mechanism to form a secreted PDZ domain-containing protein 2 (sPDZD2) with unknown functions in humans. In this study, we demonstrate the endogenous expression of PDZD2 and secretion of sPDZD2 in cancerous DU145, PC-3, 22Rv1, LNCaP, and immortalized RWPE-1 prostate epithelial cells. Inhibition of endogenous sPDZD2 production and secretion by DU145, PC-3, 22Rv1, and RWPE-1 cells via the caspase-3 inhibitor Z-DEVD-FMK resulted in increased cell proliferation, which was abrogated by treatment with exogenous recombinant sPDZD2. Whereas sPDZD2-induced antiproliferation in DU145, PC-3, and 22Rv1 cells, it induced apoptosis in LNCaP cells. The data suggest that endogenous sPDZD2, produced by caspase-3-mediated cleavage from PDZD2, may function as a novel autocrine growth suppressor for human prostate cancer cells. The antiproliferative effect of sPDZD2 was apparently mediated through slowing the entry of DU145, PC-3, and 22Rv1 cells into the S phase of the cell cycle. In DU145 cells, this can be attributed to stimulated p53 and p21 CIP1/WAF1 expression by sPDZD2. On the other hand, the apoptotic effect of sPDZD2 on LNCaP cells was apparently mediated via p53-independent Bad stimulation. Together our results indicate the presence of p53-dependent and p53-independent PDZD2/sPDZD2 autocrine growth suppressive signaling pathways in human prostate cancer cells and suggest a novel therapeutic approach of harnessing the latent tumor-suppressive potential of an endogenous autocrine signaling protein like sPDZD2 to inhibit prostate cancer growth. Copyright © 2006 by The Endocrine Society.postprin

Provision of reinforcement in concrete solids using the generalized genetic algorithm

A generalized genetic algorithm has been developed to find the global optimal reinforcement contents for a concrete solid structure subjected to a general three-dimensional (3D) stress field. Feasible solutions were examined based on the genetic algorithm, and the heterogeneous strategy used ensures that all of the local optimal regions are searched and the most optimal reinforcement content found. The effectiveness of the proposed approach has been validated by comparing the steel contents evaluated using the present method with those obtained from other available methods. A more economic design is achieved by the proposed algorithm. The method developed provides the designer with a valuable tool for the determination of reinforcements in complicated solid concrete structures. © 2011 American Society of Civil Engineers.postprin

Emission mechanism of GeV-quiet soft gamma-ray pulsars: a case for peculiar geometry?

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Improvement of protective coating on Nd–Fe–B magnet by pulse nickel plating

Author name used in this publication: C. W. ChengAuthor name used in this publication: F. T. ChengVersion of RecordPublishe

The relationship between brand trust, online customer reviews and willingness to purchase

This research investigates how online customer reviews, a particular form of electronic word of mouth (eWOM), affect consumer decision-making (willingness to purchase) during a first time purchase of services or products. Using brand trust as a mediating variable in the relationship between online customers reviews and the consumer’s willingness to buy, data was collected through a quasi-experiment approach and then analyzed using Structural Equation Modelling. The findings demonstrated that the reliable dimension of brand trust has a mediating effect on online customer reviews valance to willingness to buy while the intentionality dimension had little effect

Fermi-lat Detection Of Pulsed Gamma-rays Above 50 Gev From The Vela Pulsar

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